gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
HER2-targeted CAR T cells (upregulated in hypoxia) recognize HER2 on tumor cells, form an immune synapse, and kill via T‑cell cytotoxic pathways (perforin/granzyme release and Fas/FasL signaling).
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
On
other_modifier
CAR expression is hypoxia-stimulated (HRE/HIF-1 responsive); recognizes extracellular domain of HER2
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05681650
disease_id_num_tar_ref
3860
drug_id_num_tar_ref
10421