gene_symbol
CEACAM5
hgnc_id
HGNC:1817
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CEA-targeted CAR-T cells bind CEA on tumor cells, become activated, and kill targets via perforin/granzyme-mediated cytolysis (with T cell effector mechanisms).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
GPI-anchored cell-surface glycoprotein; tumor-associated antigen overexpressed on epithelial cancers
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06006390
disease_id_num_tar_ref
3862
drug_id_num_tar_ref
10428