gene_symbol
DLL3
hgnc_id
HGNC:2909
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
ADC binds DLL3 on tumor cells, is internalized, and releases a cytotoxic payload inside the cell, causing death of DLL3-expressing cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface Notch pathway ligand; tumor-associated antigen targeted by ADC for internalization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06179069
disease_id_num_tar_ref
3872
drug_id_num_tar_ref
10450