gene_symbol
TACSTD2
hgnc_id
HGNC:11530
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Antibody–drug conjugate binds TROP2, is internalized, and releases SN-38 (topoisomerase I inhibitor), causing DNA damage, replication arrest, and apoptosis of the target cell.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface antigen; ADC binding/internalization enables SN-38 delivery
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05833867
disease_id_num_tar_ref
329
drug_id_num_tar_ref
936