gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Native TCRs on infused TILs recognize the tumor-associated peptide–HLA complex and directly kill the presenting cell via perforin/granzyme release and Fas–FasL–mediated apoptosis.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
HLA class I and/or class II restriction depending on TIL subset (CD8 vs CD4)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05971576
disease_id_num_tar_ref
3880
drug_id_num_tar_ref
10468