gene_symbol
CCR4
hgnc_id
HGNC:1605
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Mogamulizumab binds CCR4 on target cells and its afucosylated IgG1 Fc engages NK-cell FcγRIIIa to trigger antibody‑dependent cellular cytotoxicity (ADCC), causing lysis/apoptosis of CCR4+ cells.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Chemokine receptor; blockade inhibits CCL17/CCL22 signaling
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06698003
disease_id_num_tar_ref
3887
drug_id_num_tar_ref
10494