gene_symbol
FCGR3A
hgnc_id
HGNC:3619
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Mogamulizumab binds CCR4 on target cells; its afucosylated Fc engages CD16a on NK cells to trigger ADCC, killing CCR4+ cells. CD16a-expressing cells act as effectors and are not directly killed.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Fc-mediated ADCC effector engagement; enhanced affinity with afucosylated IgG1
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06698003
disease_id_num_tar_ref
3887
drug_id_num_tar_ref
10494