gene_symbol
GPC2
hgnc_id
HGNC:4450
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
GPC2-specific CAR engagement activates T cells to kill GPC2-positive cells via perforin/granzyme-mediated cytolysis and apoptosis pathways (e.g., Fas–FasL).
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
GPI-anchored cell-surface heparan sulfate proteoglycan; tumor-associated antigen on neuroblastoma/retinoblastoma
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05650749
disease_id_num_tar_ref
3892
drug_id_num_tar_ref
10506