gene_symbol
CD22
hgnc_id
HGNC:1643
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
ADC binds CD22, is internalized, and releases calicheamicin that binds the DNA minor groove, causing double‑strand breaks and apoptosis of the target cell.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Siglec-2
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06427330
disease_id_num_tar_ref
3894
drug_id_num_tar_ref
10508