gene_symbol
UNKNOWN
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The ADC targets CD22 on B cells, is internalized, and releases calicheamicin, which binds the DNA minor groove to cause double‑strand breaks and apoptosis. The DNA minor groove is not the targeting antigen.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Calicheamicin payload target; induces double-strand breaks
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06427330
disease_id_num_tar_ref
3894
drug_id_num_tar_ref
10508