gene_symbol
TACSTD2
hgnc_id
HGNC:11530
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Antibody–drug conjugate binds TROP2, is internalized, and releases SN-38 (topoisomerase I inhibitor) causing DNA damage and apoptosis; also enables bystander killing.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface antigen bound by hRS7 antibody component of the ADC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05535218
disease_id_num_tar_ref
3903
drug_id_num_tar_ref
10539