gene_symbol
TOP1
hgnc_id
HGNC:11986
binding_type
other
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
After Trop-2–mediated uptake (and bystander diffusion), the SN-38 payload inhibits topoisomerase I, stabilizing Topo I–DNA complexes and causing DNA damage and apoptosis; cells are not selected by Topo I expression itself.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cytotoxic payload SN-38 inhibits TOP1 by stabilizing Topo I-DNA complexes
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05535218
disease_id_num_tar_ref
3903
drug_id_num_tar_ref
10539