gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
ADC binds HER2 (ECD2/ECD4), is internalized, and releases MMAE to inhibit tubulin polymerization, causing mitotic arrest and apoptosis; Fc-mediated ADCC/CDC may also contribute.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Extracellular domain epitope ECD4 (trastuzumab-like)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05804864
disease_id_num_tar_ref
3915
drug_id_num_tar_ref
10565