gene_symbol
CD276
hgnc_id
HGNC:19137
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The ADC binds B7-H3 on target cells, is internalized, and a protease-cleavable linker releases a duocarmycin payload that alkylates DNA (minor groove, N3 adenine), causing DNA damage and cell death.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface B7 family checkpoint antigen on tumor/tumor microenvironment; antibody component binds and is internalized
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06227546
disease_id_num_tar_ref
31
drug_id_num_tar_ref
79