gene_symbol
CLDN18
hgnc_id
HGNC:2039
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CAR-NK cells recognize CLDN18.2 via the CAR and kill target cells by degranulation with perforin and granzymes, causing cytolysis/apoptosis.
enzyme_product
Off
epitope
On
variant
Off
isoform
On
hla_specific
Off
gated
Off
other_modifier
Binds extracellular domain of the CLDN18.2 isoform on tumor cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06464965
disease_id_num_tar_ref
3922
drug_id_num_tar_ref
10592