gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The ADC binds HER2 (not beta-tubulin), is internalized, and releases MMAE, which inhibits beta-tubulin polymerization to cause G2/M arrest and apoptosis; killing is driven by HER2 targeting (with possible bystander effect), not by beta-tubulin expression itself.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Vinca-binding site; MMAE payload inhibits tubulin polymerization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05578287
disease_id_num_tar_ref
3929
drug_id_num_tar_ref
10611