gene_symbol
MICB
hgnc_id
HGNC:7091
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CLN-619 binds MICB on tumor cells and engages Fcγ receptors on effector cells to drive ADCC/ADCP; it also prevents MICB shedding, enhancing NKG2D-mediated NK/CTL cytotoxicity against the target-expressing cells.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds alpha3 domain; inhibits proteolytic shedding
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06381141
disease_id_num_tar_ref
3933
drug_id_num_tar_ref
10627