gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
other
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Osimertinib irreversibly inhibits mutant EGFR (exon 19 deletions) kinase activity, shutting down MAPK/PI3K-AKT survival signaling and inducing apoptosis of the EGFR-mutant tumor cells.
enzyme_product
Off
epitope
Off
variant
On
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Irreversible covalent binding at kinase Cys797 (e.g., delE746_A750)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05816252
disease_id_num_tar_ref
3934
drug_id_num_tar_ref
10631