gene_symbol
TACSTD2
hgnc_id
HGNC:11530
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The ADC binds TROP-2, is internalized, and releases a cleavable topoisomerase I inhibitor payload intracellularly, inhibiting DNA replication and causing cell cycle arrest and apoptosis of TROP-2–expressing cells.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
cell-surface transmembrane glycoprotein; mediates ADC internalization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06144723
disease_id_num_tar_ref
3943
drug_id_num_tar_ref
10642