gene_symbol
CEACAM5
hgnc_id
HGNC:1817
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Anti-CEA CAR T cells bind CEACAM5 on target cells; CAR signaling activates T-cell cytotoxicity leading to perforin/granzyme-mediated lysis (and Fas/FasL apoptosis) of CEA-positive cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
GPI-anchored cell-surface glycoprotein; tumor-associated antigen
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06768151
disease_id_num_tar_ref
335
drug_id_num_tar_ref
947