gene_symbol
CD276
hgnc_id
HGNC:19137
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
IgG-based bispecific T‑cell engager crosslinks CD276 on target cells with CD3 on T cells, forming an immune synapse and activating T cells to kill CD276+ cells via perforin/granzyme (and apoptotic) pathways; may also eliminate CD276+ tumor endothelium.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Expressed on tumor cells and tumor endothelial cells (vasculature)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05999396
disease_id_num_tar_ref
3945
drug_id_num_tar_ref
10645