gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The antibody binds CD3 on T cells to recruit/activate them; these T cells then kill CD276-positive tumor/endothelial cells via T-cell cytotoxicity (perforin/granzyme). CD3+ cells are not the targets of killing.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
CD3 complex on T cells; specific subunit not specified
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05999396
disease_id_num_tar_ref
3945
drug_id_num_tar_ref
10645