gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Cetuximab coats EGFR+ cells and engages Fcγ receptors on NK cells/macrophages to induce antibody-dependent cellular cytotoxicity (and some complement-mediated lysis), while also blocking EGFR signaling (antiproliferative).
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds extracellular domain (domain III), blocks ligand binding and receptor dimerization; IgG1 Fc can mediate ADCC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06179160
disease_id_num_tar_ref
3947
drug_id_num_tar_ref
10651