gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Fc-mediated ADCC: trastuzumab binds HER2 on tumor cells and its Fc engages Fcγ receptors on NK cells/macrophages, triggering cytolytic degranulation and lysis of HER2-positive cells (with minimal complement involvement).
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds extracellular domain IV epitope on HER2 to block signaling and enable ADCC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05786716
disease_id_num_tar_ref
3948
drug_id_num_tar_ref
10660