gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Pertuzumab binds HER2 and its Fc engages Fcγ receptor–bearing immune cells to mediate ADCC against HER2+ cells; blockade of HER2 heterodimerization also inhibits survival signaling and can induce apoptosis.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds extracellular domain II (dimerization interface) to block HER2 heterodimerization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05786716
disease_id_num_tar_ref
3948
drug_id_num_tar_ref
10661