gene_symbol
CLDN18
hgnc_id
HGNC:2039
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Autologous CAR-T cells bind CLDN18.2 on target cells and, upon CAR signaling, kill them via perforin/granzyme-mediated cytolysis (with cytokine release).
enzyme_product
Off
epitope
On
variant
Off
isoform
On
hla_specific
Off
gated
Off
other_modifier
Targets isoform 2-specific extracellular epitope of CLDN18
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05946226
disease_id_num_tar_ref
3953
drug_id_num_tar_ref
10672