gene_symbol
CD22
hgnc_id
HGNC:1643
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CAR-T cells recognize CD22 on target cells; CAR signaling (CD3ΞΆ with costimulation) activates T cells to kill via perforin/granzyme release and death-receptor pathways, leading to lysis/apoptosis of CD22+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface B-cell antigen
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT07093086
disease_id_num_tar_ref
3955
drug_id_num_tar_ref
10678