gene_symbol
CD38
hgnc_id
HGNC:1667
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Isatuximab binds CD38 on target cells and triggers Fc-mediated ADCC and complement-dependent cytotoxicity; it can also directly induce apoptosis, killing CD38+ cells.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Type II transmembrane ectoenzyme (ADP-ribosyl cyclase/cADPR hydrolase) expressed on plasma cells and other hematologic cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06561854
disease_id_num_tar_ref
3959
drug_id_num_tar_ref
10689