gene_symbol
CLDN18
hgnc_id
HGNC:2039
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CAR-T cells recognize CLDN18.2 and, upon activation, directly lyse target cells via perforin/granzyme release (and Fas–FasL apoptosis).
enzyme_product
Off
epitope
On
variant
Off
isoform
On
hla_specific
Off
gated
Off
other_modifier
Extracellular loop epitope on gastric-specific CLDN18.2
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06353152
disease_id_num_tar_ref
3963
drug_id_num_tar_ref
10698