gene_symbol
CD3E
hgnc_id
HGNC:1674
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Blinatumomab binds CD3 on T cells to activate and redirect them to CD19+ cells; T cells kill CD19+ targets via perforin/granzyme, not the CD3+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
T-cell arm (binds CD3ε on T cells)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06287229
disease_id_num_tar_ref
336
drug_id_num_tar_ref
951