gene_symbol
HLA-DRB1
hgnc_id
HGNC:4948
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
TCR-engineered T cells recognize the HPV18-derived peptide presented by HLA-DRB1*09:01 on tumor cells and directly kill them via perforin/granzyme and death receptor pathways.
enzyme_product
Off
epitope
Off
variant
On
isoform
Off
hla_specific
On
gated
Off
other_modifier
MHC class II allele restriction; binds HPV18 peptide
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05787535
disease_id_num_tar_ref
3970
drug_id_num_tar_ref
10722