gene_symbol
CD22
hgnc_id
HGNC:1643
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The anti-CD22 ADC binds CD22, is internalized, and releases calicheamicin intracellularly, causing DNA double-strand breaks and apoptosis of CD22-positive cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
B-cell surface antigen (Siglec-2) recognized by the antibody moiety
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06287229
disease_id_num_tar_ref
336
drug_id_num_tar_ref
952