gene_symbol
HLA-G
hgnc_id
HGNC:4964
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Anti–HLA-G CAR-T cells bind HLA-G on target cells and induce T-cell–mediated killing via perforin/granzyme release and Fas–FasL apoptosis.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
Nonclassical MHC class I (HLA class Ib) molecule expressed on tumor cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05672459
disease_id_num_tar_ref
3978
drug_id_num_tar_ref
10743