gene_symbol
MSLN
hgnc_id
HGNC:7371
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The ADC binds mesothelin on target cells, is internalized, and a cleavable linker releases a tubulysin microtubule-disrupting payload, causing microtubule depolymerization, G2/M arrest, and apoptosis.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface tumor-associated antigen
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05804526
disease_id_num_tar_ref
3983
drug_id_num_tar_ref
10753