gene_symbol
UNKNOWN
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The ADC binds CD22 on B cells, is internalized, then releases calicheamicin that binds the DNA minor groove to cause double‑strand breaks and apoptosis. Killing is determined by CD22 expression, not by DNA minor‑groove expression.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
ADC payload (calicheamicin) binds DNA minor groove causing double-strand breaks
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06287229
disease_id_num_tar_ref
336
drug_id_num_tar_ref
952