gene_symbol
CD274
hgnc_id
HGNC:17635
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
An anti–PD-L1 nanobody delivers Lu-177 beta radiation to PD-L1–expressing cells, causing DNA double-strand breaks and radiation-induced cell death (with possible crossfire to nearby cells).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
cell-surface immune checkpoint ligand targeted by Lu-177-labeled nanobody
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06305962
disease_id_num_tar_ref
4000
drug_id_num_tar_ref
10791