gene_symbol
CD3E
hgnc_id
HGNC:1674
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
CC312 engages CD3 (and CD28) on T cells to activate them and bridge to CD19+ B cells; the activated T cells kill the CD19+ targets via perforin/granzyme-mediated cytotoxicity, not the CD3+ T cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
CD3-TCR complex; epsilon chain commonly targeted by anti-CD3 binders
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06888960
disease_id_num_tar_ref
4015
drug_id_num_tar_ref
10829