gene_symbol
ADGRE2
hgnc_id
HGNC:3337
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CAR T cells recognize ADGRE2 (with CLEC12A co-recognition) and directly lyse target cells via perforin/granzyme-mediated cytotoxicity.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
On
other_modifier
Cooperative/dual-CAR; AND-like activation with CLEC12A co-expression to enhance selectivity
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05748197
disease_id_num_tar_ref
4022
drug_id_num_tar_ref
10841