gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Brentuximab vedotin selectively binds CD30, is internalized, and releases MMAE that binds the beta-tubulin vinca site to disrupt microtubules, causing G2/M arrest and apoptosis in CD30-positive cells (ADCC may also contribute). Beta-tubulin expression alone is not directly targeted.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
MMAE payload binds beta-tubulin at the vinca site, inhibiting microtubule polymerization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06563245
disease_id_num_tar_ref
340
drug_id_num_tar_ref
968