gene_symbol
CLEC12A
hgnc_id
HGNC:31713
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CAR T cells engage CLEC12A (in a cooperative dual-CAR with ADGRE2), triggering CAR signaling that activates T-cell cytotoxicity (perforin/granzyme release and death-receptor pathways) to lyse CLEC12A-positive cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
On
other_modifier
Cooperative/dual-CAR; AND-like activation with ADGRE2 co-expression to enhance selectivity
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05748197
disease_id_num_tar_ref
4022
drug_id_num_tar_ref
10841