gene_symbol
KIT
hgnc_id
HGNC:6342
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The anti-CD117 IgG1 binds c-KIT on CD117+ cells, blocks SCF–c-KIT survival signaling, and engages Fcγ receptor–bearing immune cells to mediate ADCC and antibody-dependent phagocytosis, depleting/killing CD117+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Receptor tyrosine kinase; binding blocks SCF–KIT signaling
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05903274
disease_id_num_tar_ref
4023
drug_id_num_tar_ref
10844