gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The mRNA vaccine primes and expands neoantigen-specific T cells; CTLs recognize neoantigen–MHC I on tumor cells and kill them via perforin/granzyme (and Fas–FasL) pathways, with CD4+ T-cell help.
enzyme_product
Off
epitope
On
variant
On
isoform
Off
hla_specific
On
gated
Off
other_modifier
Individualized set of mutated peptide epitopes presented on HLA class I to activate CD8+ T cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05968326
disease_id_num_tar_ref
4025
drug_id_num_tar_ref
10849