gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The mRNA vaccine primes neoantigen‑specific CD4+ (MHC II–restricted) and CD8+ T cells via APC presentation; these T cells then recognize the neoantigen peptides on tumor cells and kill them via perforin/granzyme and/or Fas–FasL pathways.
enzyme_product
Off
epitope
On
variant
On
isoform
Off
hla_specific
On
gated
Off
other_modifier
Individualized set of mutated peptide epitopes presented on HLA class II to activate CD4+ T cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05968326
disease_id_num_tar_ref
4025
drug_id_num_tar_ref
10849