gene_symbol
TIGIT
hgnc_id
HGNC:26838
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
IgG1 Fc engages Fcγ receptors to mediate ADCC/ADCP against TIGIT-high cells (e.g., Tregs) bound by the antibody, leading to their depletion.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Fc-competent IgG1; blocks TIGIT interaction with CD155 (PVR) and CD112 (NECTIN2) and can mediate ADCC of TIGIT-high Tregs
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06472076
disease_id_num_tar_ref
4028
drug_id_num_tar_ref
10863