gene_symbol
BCL2
hgnc_id
HGNC:990
binding_type
other
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Venetoclax directly inhibits BCL-2 as a BH3 mimetic, freeing BAX/BAK to induce mitochondrial outer membrane permeabilization, cytochrome c release, and caspase-mediated apoptosis in BCL-2–dependent cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
BH3-binding groove (hydrophobic pocket)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06387420
disease_id_num_tar_ref
4041
drug_id_num_tar_ref
10904