gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The ADC binds HER2 on target cells, is internalized, and releases the MMAE payload, which disrupts microtubules causing mitotic arrest and apoptosis; Fc engagement can also trigger ADCC.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Extracellular domain; effective even at low HER2 expression
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05861635
disease_id_num_tar_ref
4044
drug_id_num_tar_ref
10907