gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
RC48 binds HER2 (not beta-tubulin); after internalization it releases MMAE, which binds the vinca site on beta-tubulin to disrupt microtubules, causing mitotic arrest and apoptosis (with possible ADCC/bystander effects).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
MMAE payload binds the vinca site to disrupt microtubules
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05861635
disease_id_num_tar_ref
4044
drug_id_num_tar_ref
10907