gene_symbol
FAP
hgnc_id
HGNC:3590
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The 177Lu-labeled FAP inhibitor binds FAP on cancer-associated fibroblasts; beta emissions from 177Lu induce DNA double-strand breaks in the FAP-expressing cells, killing them, with crossfire irradiation of nearby tumor cells.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface serine protease highly expressed on cancer-associated fibroblasts (CAFs)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06197139
disease_id_num_tar_ref
4045
drug_id_num_tar_ref
10909