gene_symbol
MS4A1
hgnc_id
HGNC:7315
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Anti-CD20 IgG1 binds CD20 on B cells and kills them via enhanced Fc gamma RIIIa–mediated ADCC and ADCP, plus direct caspase-independent cell death (with minimal complement-mediated cytotoxicity).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Type II anti-CD20 binding; glycoengineered Fc enhances Fc gamma RIIIa-mediated ADCC/ADCP
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05896163
disease_id_num_tar_ref
4051
drug_id_num_tar_ref
10921