gene_symbol
TOP1
hgnc_id
HGNC:11986
binding_type
other
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
After the ADC binds TROP2 and is internalized, the DXd payload is released and inhibits DNA topoisomerase I, causing DNA breaks, S-phase arrest, and apoptosis; payload can also diffuse to nearby cells (bystander killing).
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
DXd payload target (topoisomerase I inhibitor)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05866432
disease_id_num_tar_ref
4066
drug_id_num_tar_ref
10959